NIMG-31. CLINICALLY RELIABLE DEEP LEARNING MODEL FOR DIFFERENTIATION OF GLIOBLASTOMA FROM SINGLE BRAIN METASTASIS: ESTIMATING UNCERTAINTY WITH DEEP ENSEMBLES

نویسندگان

چکیده

Abstract OBJECTIVES To develop a clinically reliable deep learning model to differentiate glioblastoma (GBM) from solitary brain metastasis by providing predictive uncertainty estimates. METHODS A total of 465 patients (300 GBM, 165 single metastasis) were enrolled in the institutional training set. Deep ensembles based on Densenet121 (2D CNN) trained multiparametric MRI. The models validated external validation set consisting 143 (101 42 metastasis). classification performance was estimated, and entropy values for each input evaluated measurement. Based values, split high low groups. evaluate out-of-distribution data unseen classes, 319 with meningiomas (from two institutions) separately tested ensemble model. RESULTS showed an AUC, accuracy, sensitivity, specificity 0.82, 78.3%, 54.8%, 88.1% differentiating GBM metastasis. higher group (AUC, 0.78, 89.0%, 62.5%, 94.2%, respectively) than 0.64, 65.5%, 51.4%, 77.1%) according validation. On dataset meningiomas, 292 (91.4%) classified as whereas only 202 (63.4%) into DenseNet121. CONCLUSIONS Not can provide metastasis, but also avoid overconfident predictions classes consequently offer clinical decision making.

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ژورنال

عنوان ژورنال: Neuro-oncology

سال: 2022

ISSN: ['1523-5866', '1522-8517']

DOI: https://doi.org/10.1093/neuonc/noac209.649